anndict.annotate.ai_determine_leiden_resolution

anndict.annotate.ai_determine_leiden_resolution(adata, initial_resolution)

Adjusts the Leiden clustering resolution of an AnnData object based on LLM feedback.

This function iteratively performs Leiden clustering on the AnnData object, generates a UMAP plot, and uses an LLM model to interpret the plot and suggest whether to increase, decrease, or maintain the current resolution. The resolution is adjusted by ±0.1 based on the LLM’s suggestion until no further adjustment is needed.

Parameters:

adata AnnData

An AnnData object.

initial_resolution float

The initial resolution for Leiden clustering.

Return type:

float

Returns:

The final resolution value after adjustments based on LLM interpretation.